Code | CSB-YP024457HU |
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Size | $250 |
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Recombinant Human E3 ubiquitin-protein ligase protein TRIM21 is a yeast-expressed full-length protein. It contains amino acid of 1-475 derived from human TRIM21 and has fused 6xHis-tags at the N-terminus. This TRIM21 protein is determined by SDS-PAGE, with purity greater than 90%. Recombinant protein has a calculated molecular weight of 56.2 kDa. The actual molecular mass increases slightly due to the post-modifications (PTMs). This product is available in stock, so you don't have to wait for the protein to be prepared when you buy it. Based on its major roles, this recombinant TRIM21 protein can be applied to the research area of epigenetics and nuclear signaling transduction.
E3 ubiquitin ligase TRIM21 is a predominant autoantigen in immune diseases and a regulator of innate immune signaling. In autoubiquitination, TRIM21 acts both as an E3 ligase and as a substrate. It also exerts antiviral functions. For instance, TRIM21 primarily facilitating the degradation of Hepatitis B virus (HBV) DNA Pol mainly through the K48-linked ubiquitin proteasome pathway via its RING domain, thus blocking HBV DNA replication. This may suggest a potential strategy for the treatment of HBV, infection of which will dvelope epatic fibrosis, cirrhosis even hepatocellular carcinoma.
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1.Is this protein functionally active?
2.How is it made? from which system?
3.Is it properly folded?
4.Does it bind to Fc?